… that some of the 7-azaindenoisoquinolines had the ability to … research led to very potent
cytotoxic anticancer agents, it also … rewarded with the extremely cytotoxic 3-fluoro derivative 62 (…

… chance to develop more effective anticancer drugs in addition to those … Design and Synthesis
of Chlorinated and Fluorinated 7-Azaindenoisoquinolines as Potent Cytotoxic Anticancer …

… potential anticancer agents targeting Topoisomerase I (TOP1), … synthesis of compounds with
different scaffolds can inhibit … TOP1 poisoning activity of the most potent cytotoxic 4-alkoxy-2-…

… anticancer drugs, dual-downregulation of MYC and … in Raji vs CA-46 cells and cytotoxicity
in MYC-dependent cell lines. … the design and synthesis of new 7-azaindenoisoquinolines and …

… Recently, we have developed a new series of 6,7-dimethoxy-4-alkoxy-2-arylquinolines as
Topoisomerase I (TOP1) inhibitors with potent anticancer activity. Utilising the SAR outputs …

… to inhibition of one class of topoisomerase enzymes is … in the development of potent, efficient
and safe anticancer agents. … only few differences in their cytotoxicity activity, which could …

… mode of inhibition, termed interfacial inhibition, was first discovered for the topoisomerase …
, in which the addition of a fluorine at position 3 replaces the methoxy groups at position 2, 3 of …

… replication by inhibiting bacterial DNA gyrase and topoisomerase IV … and anticancer
compounds contained the 6-fluoro and 7-… The more potent cytotoxicity of 6g might be due to a …

… activity of TP inhibitors in combination with other anticancer drugs is less. Therefore, it is …
affect for potency, and the introduction fluorine showed better activity than the chlorine group at …

… 16 with fluoro substitution resulted in marked decrease in the … To our satisfaction, compound
3 was found to be less cytotoxic in … the way for the development of effective anticancer drugs. …